Moussa B H Youdim Selected Research

(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate

3/2013	Multi target neuroprotective and neurorestorative anti-Parkinson and anti-Alzheimer drugs ladostigil and m30 derived from rasagiline.
4/2012	Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment.
1/2011	A novel anti-Alzheimer's disease drug, ladostigil neuroprotective, multimodal brain-selective monoamine oxidase and cholinesterase inhibitor.
1/2010	Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation.
2/2009	The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats.
9/2008	The neuroprotective effect of ladostigil against hydrogen peroxide-mediated cytotoxicity.
5/2008	The neuroprotective mechanism of action of the multimodal drug ladostigil.
12/2007	Induction of neurotrophic factors GDNF and BDNF associated with the mechanism of neurorescue action of rasagiline and ladostigil: new insights and implications for therapy.
10/2007	Aminoindan and hydroxyaminoindan, metabolites of rasagiline and ladostigil, respectively, exert neuroprotective properties in vitro.
12/2006	The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and m30.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Moussa B H Youdim Research Topics

Disease

75	Parkinson Disease (Parkinson's Disease) 10/2021 - 01/2002
62	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2018 - 01/2002
54	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 01/2002
30	Neuroblastoma 01/2017 - 01/2002
16	Dementia (Dementias) 03/2013 - 03/2002
16	Parkinsonian Disorders (Parkinsonism) 01/2012 - 08/2002
15	Hypoxia (Hypoxemia) 01/2017 - 01/2005
11	Inflammation (Inflammations) 01/2017 - 08/2004
9	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2017 - 03/2004
7	Schizophrenia (Dementia Praecox) 01/2017 - 06/2006
7	Lewy Body Disease (Lewy Body Dementia) 09/2011 - 05/2003
6	Cognitive Dysfunction 01/2017 - 03/2004
6	Neoplasms (Cancer) 04/2013 - 11/2006
6	Pheochromocytoma 01/2012 - 01/2002
5	Neuroinflammatory Diseases 10/2017 - 01/2016
5	Mitochondrial Diseases (Mitochondrial Disease) 02/2016 - 01/2007
5	Disease Progression 09/2011 - 01/2003
5	Huntington Disease (Huntington's Disease) 09/2007 - 03/2004
4	Ischemia 03/2013 - 01/2005
4	Nervous System Diseases (Neurological Disorders) 10/2008 - 03/2004
4	Friedreich Ataxia (Friedreich's Ataxia) 02/2006 - 02/2004
3	Amyloid Plaque 01/2022 - 05/2012
3	Memory Disorders (Memory Loss) 01/2016 - 09/2012
3	Cardiovascular Diseases (Cardiovascular Disease) 05/2011 - 11/2006
3	Craniocerebral Trauma (Head Injury) 06/2005 - 01/2005
2	Retinitis Pigmentosa (Pigmentary Retinopathy) 10/2021 - 10/2017
2	Depressive Disorder (Melancholia) 11/2018 - 01/2006
2	Brain Ischemia (Cerebral Ischemia) 12/2013 - 03/2004

Drug/Important Bio-Agent (IBA)

62	IronIBA 01/2022 - 01/2002
43	rasagiline (Azilect)FDA Link 11/2018 - 04/2002
43	Pharmaceutical PreparationsIBA 01/2018 - 03/2002
40	Monoamine Oxidase (MAO)IBA 01/2022 - 04/2002
34	Chelating AgentsIBA 01/2022 - 03/2004
31	Neuroprotective AgentsIBA 10/2017 - 01/2002
31	Proteins (Proteins, Gene)FDA Link 01/2017 - 08/2002
19	(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamateIBA 03/2013 - 03/2002
18	AntioxidantsIBA 11/2018 - 01/2002
18	NeurotoxinsIBA 01/2014 - 08/2002
18	PolyphenolsIBA 12/2012 - 01/2002
17	TeaIBA 12/2012 - 01/2002
14	Amyloid (Amyloid Fibrils)IBA 01/2022 - 08/2002
14	Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA 11/2018 - 12/2002
13	Cholinesterases (Cholinesterase)IBA 01/2022 - 10/2002
13	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 03/2015 - 10/2002
11	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2016 - 03/2004
10	propargylamineIBA 09/2017 - 04/2005
10	Dopamine (Intropin)FDA LinkGeneric 01/2017 - 04/2003
9	MetalsIBA 01/2022 - 09/2004
8	Selegiline (E250)FDA LinkGeneric 11/2018 - 04/2002
8	Oxidopamine (6 Hydroxydopamine)IBA 03/2015 - 01/2002
8	N-propargylIBA 08/2012 - 04/2002
7	Antidepressive Agents (Antidepressants)IBA 11/2018 - 03/2002
7	Therapeutic UsesIBA 01/2017 - 12/2006
7	UbiquitinIBA 01/2012 - 08/2004
6	Complementary DNA (cDNA)IBA 12/2004 - 10/2002
5	Brain-Derived Neurotrophic Factor (BDNF)IBA 11/2018 - 08/2005
5	Antipsychotic Agents (Antipsychotics)IBA 01/2017 - 06/2006
5	Serotonin (5 Hydroxytryptamine)IBA 01/2017 - 02/2005
5	Cholinesterase Inhibitors (Anticholinesterases)IBA 10/2016 - 06/2004
5	EnzymesIBA 01/2016 - 12/2002
5	Oxyquinoline (8 Hydroxyquinoline)FDA Link 06/2014 - 01/2010
5	Cholinergic Agents (Cholinergics)IBA 07/2012 - 02/2005
5	Proteasome Endopeptidase Complex (Proteasome)IBA 11/2009 - 08/2004
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2018 - 11/2009
4	LithiumIBA 04/2013 - 06/2004
4	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 04/2012 - 06/2006
4	methyl carbamateIBA 04/2012 - 10/2002
4	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2012 - 11/2009
4	FlavonoidsIBA 01/2012 - 03/2004
4	Levodopa (L Dopa)FDA LinkGeneric 11/2010 - 01/2005
4	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 11/2009 - 01/2008
4	Catechin (Z 7300)IBA 10/2008 - 08/2004
4	(N-propargyl-(3R) and (3S) aminoindan-5-yl)-ethyl methyl carbamateIBA 06/2004 - 10/2002
3	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 11/2018 - 01/2012
3	Erythropoietin FDA Link 11/2018 - 01/2012
3	Nerve Growth Factors (Neurotrophins)IBA 11/2018 - 01/2012
3	Rivastigmine (Exelon)FDA LinkGeneric 01/2017 - 10/2006
3	Glutamic Acid (Glutamate)FDA Link 02/2016 - 10/2003
3	Ethanol (Ethyl Alcohol)IBA 01/2015 - 08/2009
3	Insulin (Novolin)FDA Link 02/2014 - 11/2009
3	Peroxynitrous Acid (Peroxynitrite)IBA 03/2013 - 11/2007
3	Biomarkers (Surrogate Marker)IBA 05/2012 - 01/2007
3	Free RadicalsIBA 01/2012 - 11/2009
3	Protein AggregatesIBA 01/2011 - 03/2004
3	Messenger RNA (mRNA)IBA 02/2009 - 08/2005
3	Caspase 3 (Caspase-3)IBA 09/2008 - 01/2007
3	neuromelaninIBA 01/2004 - 01/2003
2	AcetylcholinesteraseIBA 01/2022 - 01/2012
2	5- (2- (methylprop- 2- ynylamino)ethyl)quinolin- 8- olIBA 10/2017 - 01/2017
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2017 - 02/2005
2	Scopolamine (Hyoscine)FDA Link 01/2017 - 01/2016
2	AcidsIBA 01/2017 - 05/2011
2	Biological ProductsIBA 10/2016 - 03/2004
2	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2016 - 04/2012
2	Donepezil (Aricept)FDA LinkGeneric 01/2016 - 06/2014
2	Oxidoreductases (Dehydrogenase)IBA 01/2016 - 02/2009
2	Peptides (Polypeptides)IBA 01/2016 - 01/2008
2	LigandsIBA 01/2016 - 09/2011
2	1-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)IBA 01/2014 - 11/2009

Therapy/Procedure

16	Therapeutics 01/2022 - 01/2002